Isotope ratio MS ( IRMS) for Profiling & Authenticity Analysis

The Thermo Scientific MAT 253 stable isotope ratio mass spectrometer system delivers the highest precision for the determination of D/ H, 13C/ 12C, 15N/ 14N, 18O/ 16O, 34S/ 32S ( from SO2 and SF6) , 28Si/ 29Si as well as Ar, Kr and Xe isotope ratios. Elemental Analyzers The Thermo Scientific ConFlo IV Universal Interface, with an installed base of over 900 units, is the most widely used interface for coupling elemental analyzers with isotope ratio mass spectrometers. It allows the connection of a wide variety of elemental analyzers to Thermo Scientific DELTA V including: Dumas combustion elemental analyzers for 13C/ 12C, 15N/ 14N and 34S/ 32S, quantitative high temperature carbon reduction elemental analyzers for D/ H and 18O/ 16O ( Thermo Scientific TC/ EA and Flash 2000 HT) , the GC-Box for analysis of components of gas mixtures, as well as custom made peripherals e.g. DOC analyzers, laser ablation devices. The automated dilution system of the ConFlo IV together with the 50 Volt amplification range of the DELTA V allow dual element analysis of C and N or H and O with a dynamic range > 1: 1000. Liquid Chromatography The Thermo Scientific LC IsoLink opens the world of HPLC separations to 13C/ 12C isotope ratio applications. Its sensitivity, precision and accuracy enable, for the first time, the compound specific isotope analysis of bioactive compounds with high polarity and high molecular weight. It offers full automation and maintenance-free operation. In addition, the LC IsoLink comes with a fully automated bulk ¼ -Elemental Analyzer mode for 13C-analysis of DOC, dissolved organic carbon. Gas Chromatography The Thermo Scientific GC IsoLink with combustion and high temperature pyrolysis is used for compound specific isotope analysis of complex mixtures separated on a capillary GC column. Determination of D/ H, 13C/ 12C, 15N/ 14N and 18O/ 16O isotope ratios is possible for all mixtures accessible by the GC technique. The GC IsoLink couples to the ConFlo IV universal interface, leveraging its benefits for isotope ratio monitoring GC/ MS. More than 800 GC-IRMS systems are installed and being used in a very large range of application. Positive identification of compounds can be achieved by simultaneous determination of isotope ratios and acquisition of full scan EI/ CI spectra, with a hybrid GC-MS/ IRMS system.